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CB1 receptors
The CB1 receptors are primarily located
on nerve cells in the brain, spinal cord, but they are also found in
some peripheral organs and tissues such as the spleen, white blood
cells, endocrine gland and parts of the reproductive, gastrointestinal
and urinary tracts.
In the brain, the CB1 receptors are abundant
in the cerebellum, basal ganglia, hippocampus and dorsal primary
afferent spinal cord regions, which is why cannabinoids influence
functions such as memory processing, physical discomfort and motor
control. (1)
CB2 receptors
The CB2 receptors are mainly found on white
blood cells, in the tonsils and in the spleen. The immune cells also
express CB1, although there are fewer of them than CB2. In the immune
system, one important function of the cannabinoid receptors is the
regulation of cytokine release.(1)
Progress in Lipid Research, P. Pacher, R. Mechoulam; 2011
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